Timothy K MacLachlan[Author] - Search Results

Year	Number of Results
2002	4
2003	3
2004	1
2005	1
2006	1
2008	1
2010	1
2011	2
2012	2
2013	1
2017	4
2018	1
2020	1
2021	2
2022	1
2024	1

1

MacLachlan TK. MacLachlan TK. Cancer Biol Ther. 2008 Aug;7(8):1313-4. doi: 10.4161/cbt.7.8.6684. Epub 2008 Aug 25. Cancer Biol Ther. 2008. PMID: 18719359 No abstract available.

2

Regulatory Consideration for the Nonclinical Safety Assessment of Gene Therapies.

Moffit JS, Blanset DL, Lynch JL, MacLachlan TK, Meyer KE, Ponce R, Whiteley LO. Moffit JS, et al. Among authors: maclachlan tk. Hum Gene Ther. 2022 Nov;33(21-22):1126-1141. doi: 10.1089/hum.2022.090. Epub 2022 Sep 14. Hum Gene Ther. 2022. PMID: 35994386 Free PMC article.

3

Insights into differential endostatin activity.

Maclachlan TK, Dhanabal M. Maclachlan TK, et al. Cancer Biol Ther. 2004 Nov;3(11):1167-8. doi: 10.4161/cbt.3.11.1300. Epub 2004 Nov 16. Cancer Biol Ther. 2004. PMID: 15640617 No abstract available.

4

Industry experiences with immune-mediated findings in biotherapeutic nonclinical toxicology studies.

MacLachlan TK, Kronenberg S, Marshall N, Andrews L, Berens SJ, Brouta F, Fogal B, Freebern W, Herzyk D, Kamperschroer C, Kiessling A, Schneidkraut M, Maier C. MacLachlan TK, et al. Regul Toxicol Pharmacol. 2021 Feb;119:104825. doi: 10.1016/j.yrtph.2020.104825. Epub 2020 Nov 19. Regul Toxicol Pharmacol. 2021. PMID: 33220389

5

The Bespoke Gene Therapy Consortium: facilitating development of AAV gene therapies for rare diseases.

Brooks PJ, Miller TM, Revah F, Suh J, Garrison BR, Starke LC, MacLachlan TK, Neilan EG, Raychaudhuri G, Kassim SH, Dehdashti J, Rutter JL. Brooks PJ, et al. Among authors: maclachlan tk. Nat Rev Drug Discov. 2024 Mar;23(3):157-158. doi: 10.1038/d41573-024-00020-8. Nat Rev Drug Discov. 2024. PMID: 38321319 No abstract available.

6

Nonclinical Safety Evaluation of scAAV8-RLBP1 for Treatment of RLBP1 Retinitis Pigmentosa.

MacLachlan TK, Milton MN, Turner O, Tukov F, Choi VW, Penraat J, Delmotte MH, Michaut L, Jaffee BD, Bigelow CE. MacLachlan TK, et al. Mol Ther Methods Clin Dev. 2017 Dec 22;8:105-120. doi: 10.1016/j.omtm.2017.12.001. eCollection 2018 Mar 16. Mol Ther Methods Clin Dev. 2017. PMID: 29359172 Free PMC article.

7

Storm forecasting: additional lessons from the CD28 superagonist TGN1412 trial.

Horvath C, Andrews L, Baumann A, Black L, Blanset D, Cavagnaro J, Hastings KL, Hutto DL, MacLachlan TK, Milton M, Reynolds T, Roberts S, Rogge M, Sims J, Treacy G, Warner G, Green JD. Horvath C, et al. Among authors: maclachlan tk. Nat Rev Immunol. 2012 Oct;12(10):740; author reply 740. doi: 10.1038/nri3192-c1. Epub 2012 Aug 31. Nat Rev Immunol. 2012. PMID: 22941443 No abstract available.

8

Classic and evolving approaches to evaluating cross reactivity of mAb and mAb-like molecules - A survey of industry 2008-2019.

MacLachlan TK, Price S, Cavagnaro J, Andrews L, Blanset D, Cosenza ME, Dempster M, Galbreath E, Giusti AM, Heinz-Taheny KM, Fleurance R, Sutter E, Leach MW. MacLachlan TK, et al. Regul Toxicol Pharmacol. 2021 Apr;121:104872. doi: 10.1016/j.yrtph.2021.104872. Epub 2021 Jan 22. Regul Toxicol Pharmacol. 2021. PMID: 33485926

9

Apoptotic threshold is lowered by p53 transactivation of caspase-6.

MacLachlan TK, El-Deiry WS. MacLachlan TK, et al. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9492-7. doi: 10.1073/pnas.132241599. Epub 2002 Jun 27. Proc Natl Acad Sci U S A. 2002. PMID: 12089322 Free PMC article.

10

Inflammation and immunogenicity limit the utility of the rabbit as a nonclinical species for ocular biologic therapeutics.

de Zafra CLZ, Sasseville VG, Matsumoto S, Freichel C, Milton M, MacLachlan TK, Farman C, Raymond I, Gupta S, Newton R, Atzpodien EA, Thackaberry EA. de Zafra CLZ, et al. Among authors: maclachlan tk. Regul Toxicol Pharmacol. 2017 Jun;86:221-230. doi: 10.1016/j.yrtph.2017.03.013. Epub 2017 Mar 16. Regul Toxicol Pharmacol. 2017. PMID: 28322894

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